Table 1.

Dosing Recommendations and Categories for Antiplatelet and Antithrombotic agents for patients undergoing percutaneous coronary intervention adapted from the American College of Cardiology/American Heart Association guidelines – 2009 update

Drug	Recommendations during PCI	Minor Excess Dosing	Major Excess Dosing
GPIs
Abciximab	Bolus 0.25 mg/kg IV; Infusion 0.125 mcg/kg/min (maximum 10 mcg/min)	0.25mg/kg> Bolus <0.275 mg/kg; 0.125 mcg/kg/min > Infusion <0.1375 mcg/kg/min	Bolus > 0.275 mg/kg; Infusion >0.1375 mcg/kg/min OR Infusion > 10 mcg/min whichever is less
Eptifibatide	Bolus 180 mcg/kg IV; Infusion 2.0 mcg/kg/min, reduce to 1.0 mcg/kg/min if CrCl<50 mL/min	180 mcg/kg > Bolus < 198 mcg/kg; 2.0 mcg/kg/min > Infusion rate < 2.2 mcg/kg/min	Bolus > 198 mcg/kg; Infusion rate > 2.2 mcg/kg/min OR; Full dose if CrCl< 50 mL/min
Bivalirudin	Bolus 0.75 mg/kg; Infusion 1.75 mg/kg/hour	0.75 mg/kg > Bolus < 0.825 mg/kg; 1.75 mg/kg/hour > Infusion rate < 1.925 mg/kg/hour	Bolus > 0.825 mg/kg; Infusion rate > 1.925 mg/kg/hour
Unfractionated Heparin	With GPIs : 50–70 U/kg No GPIs: 70–100 U/kg; Infusion rate: 12–15 U/kg/hour	With GPIs: 70U kg >UFH bolus<77 U/kg ; No GPIs: 100 U/kg> UFH bolus< 110 U/kg; 15 U/kg/hour> Infusion <16.5 U/kg/hour	With GPIs : UFH bolus> 77 U/kg; No GPIs: UFH bolus> 110 U/kg; Infusion>16.5 U/kg/hour

Abbreviations: CrCl – Creatinine clearance