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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Biol Psychiatry. 2014 Dec 13;79(2):87–96. doi: 10.1016/j.biopsych.2014.11.022

Figure 3. Psychological stress/psychopathology findings in animal and human studies.

Figure 3

Significant findings reported from animal and human studies examining the effects of psychological stress/psychopathology according to the NR3C1 first exon variant investigated. Publications are numbered according to their position in the reference list. Upward arrow indicates increased methylation while downward arrow indicates decreased methylation. Results were reported as mean methylation of the region investigated unless otherwise indicated by the footnotes.

a. CpGs 10 & 21; BN vs. no eating disorder. b. In BN+BPD vs. BN no BPD/no eating disorder. c. no detectable methylation on NR3C1 CpGs. d. Acute stress group – ↑ methylation at several CpG sites in hippocampus only; Chronic stress group – ↑ methylation in response to psychosocial stress in adrenal and pituitary, ↑ methylation in adrenal and ↓ methylation in the pituitary in response to restraint stress. e. No change over time and no difference between responders and non-responders. f. CpGs 3 & 4.