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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Bioorg Med Chem. 2014 Dec 13;23(14):3913–3924. doi: 10.1016/j.bmc.2014.12.007

Table 1.

Effect of the compounds on Ca2+ mobilization in FPR1/FPR2 transfected cells, human and mouse neutrophils

graphic file with name nihms649342t1.jpg
Compound FPR1 FPR2 Human PMN
(w/o
probenecid)		 Human PMN
(with
probenecid)		 Mouse PMN
EC50, µM (Efficacy, %)
(S)-9a 0.43 ± 0.13
(130)		 0.096 ± 0.027
(120)		 0.064 ± 0.026
(100)		 0.060 ± 0.021
(105)		 0.24 ± 0.07
(110)
(R)-9a N.A. 0.23 ± 0.083
(100)		 0.92 ± 0.28
(40)		 0.88 ± 0.25
(95)		 4.9 ± 1.4
(30)
(S)-9b N.A. 1.6 ± 0.36
(115)		 12.6 ± 3.7
(55)		 0.66 ± 0.18
(130)		 1.7 ± 0.44
(50)
(R)-9b N.A. N.A. N.A. N.A. 2.3 ± 0.73
(65)
(S)-9c N.A. N.A. N.A. N.A. 2.5 ± 0.61
(60)
(R)-9c N.A. 0.26 ± 0.064
(65)		 N.A. 0.97 ± 0.34
(40)		 3.8 ± 1.3
(35)
(S)-9d N.A. 0.73 ± 0.23
(75)		 1.8 ± 0.42
(30)		 0.27 ± 0.082
(105)		 3.9 ± 1.5
(75)
(R)-9d N.A. N.A. N.A. N.A. 2.1 ± 0.58
(80)
(S)-9e 0.95 ± 0.26
(115)		 0.43 ± 0.11
(135)		 1.8 ± 0.37
(85)		 0.45 ± 0.13
(120)		 2.8 ± 0.64
(80)
(R)-9e N.A. 0.31 ± 0.092
(90)		 0.62 ± 0.24
(40)		 0.49 ± 0.16
(115)		 1.0 ± 0.27
(55)
(S)-9f N.A. 0.86 ± 0.21
(40)		 N.A. 1.1 ± 0.36
(55)		 2.3 ± 0.35
(25)
(R)-9f N.A. N.A. N.A. N.A. 2.5 ± 0.42
(25)