Table 3.
Stability of Selected Compounds and 7 (PD-176252) after Incubation with Rat Microsomes
| Compound | t1/2 (min) | CLint (µL/min/mg) |
|---|---|---|
| (S)-9a | 1.1 | 1162.4 |
| (R)-9a | 1.2 | 1290.6 |
| (R)-9e | 0.6 | 2476.0 |
| (S)-9e | 0.6 | 2173.4 |
| 7 (PD-176252) | 4.4 | 314.1 |
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