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Germline configuration of VLR genes in lampreys and hagfish (modified from [89]). The three pairs of orthologous germline VLRA, VLRC, and VLRB genes are different in lampreys and hagfish. Notably, sea lamprey VLRB has a 5' LRRCT- encoding donor sequence in the large intervening region, whereas the other VLR genes do not and they possess shorter intervening sequences. (not drawn to scale)
