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Model of B- cell and T-cell like lineages in jawless vertebrates (modified from [90]). Cognate antigens (Ag) stimulate VLRA+, VLRC+ and VLRB+ lymphocytes, but whether or not VLRA and VLRC see native or processed antigens is unknown. Antigen-stimulated VLRB cells differentiate into VLRB-secreting plasma cells, whereas activated VLRA and VLRC cells do not secrete their receptors.
