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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Cell Immunol. 2015 May 1;296(1):87–94. doi: 10.1016/j.cellimm.2015.04.007

Figure 5.

Figure 5

Structures of the three VLR isotypes. (A) VLRB binds to hen egg lysozyme (HEL) using multiple β-strands on its concave surface and insertion of the LRRCT variable loop into the catalytic cleft. (VLRB.2D, PDB ID: 3G3A) (B) VLRA also binds to HEL using its concave surface, but the LRRCT loop packs against the side of HEL, instead of inserting in the catalytic site. (VLRA.R2.1, PDB ID: 3M18) (C) Unlike VLRA and VLRB, VLRC does not have a protruding loop in the LRRCT, and the LRRCT sequence is almost invariant. (PDB ID: 3WO9, LRRCT is indicated in red and LRRNT in blue)