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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Exp Eye Res. 2015 Apr 23;136:38–44. doi: 10.1016/j.exer.2015.04.014

Figure 3. ICP elevation is stable and does not impact IOP.

Figure 3

A. Acute ICP elevation in an anesthetized mouse. ICP rose to approximately 30 mmHg immediately after increasing artificial CSF flow. IOP was measured every 5 minutes before and after acute ICP elevation and did not change in either eye. ICP measurements in this panel were collected at 250 Hz. B. Daily post-operative (POD = post-operative day) ICP measurements in mice exposed to sustained elevated ICP (elevated ICP, squares; n = 6) or normal ICP (control, circles; n = 6). ICP was originally at baseline (as in panel A) prior to elevation of ICP. Once elevated, ICP was maintained at the same level for the duration of the study. ICP was significantly higher in the experimental group. At some time points the error bars (one SEM) were so small that they were beyond the resolution of the figure. ICP for each mouse at each time point was calculated as an average of 1 hour data collection at 4 Hz.