Table 3. Incidence of main histological findings in nude mice with Ramos xenografts treated with 530 MBq/kg 177Lu-HH1, 177Lu-rituxmab and 177Lu-IgG1 non-specific isotype control or 0.9% NaCl.
| Incidence (% (number of mice affected/total number of mice)) | |||||
|---|---|---|---|---|---|
| Organ | Histological finding | NaCl | 530 MBq/kg 177Lu-HH1 | 530 MBq/kg 177Lu-rituximab | 530 MBq/kg 177Lu-IgG1 |
| Bone marrow | Reduced cellularity | 0 (0/10) | 11 (1/9) | 60 (6/10) | 30 (3/10) |
| Colon | Lymphoid depletion | 0 (0/9) | 0 (0/9) | 30 (3/10) | 30 (3/10) |
| Ileum | Lymphoid depletion | 0 (0/10) | 11 (1/9) | 10 (1/10) | 10 (1/10) |
| Liver | Extramedullary hematopoiesis | 0 (0/10) | 0 (0/9) | 0 (0/10) | 40 (4/10) |
| Inflamatory cell infiltration | 50 (5/10) | 11 (1/9) | 10 (1/10) | 0 (0/10) | |
| Ovaries | Atretic follicles (present) | 0 (0/10) | 89 (8/9) | 40 (4/10) | 100 (8/8) |
| Intersticial cell hyperplasia | 0 (0/10) | 78 (7/9) | 40 (4/10) | 50 (4/8) | |
| Spleen | Extramedullary hematopoiesis | 100 (10/10) | 89 (8/9) | 40 (4/10) | 100 (10/10) |
| Lymphoid depletion | 10 (1/10) | 22 (2/9) | 60 (6/10) | 80 (8/10) | |
| Pigmented macrophages | 0 (0/10) | 11 (1/9) | 60 (6/10) | 10 (1/10) | |