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. 2015 Jun 11;11(6):e1004920. doi: 10.1371/journal.ppat.1004920

Fig 8. Temporal course of functional and disrupted cell cycle control on parvovirus assembly.

Fig 8

A. Parvovirus assembly and maturation is timely coupled to cell cycle progression from G1 to G2. Phosphorylated VPs trimers translocate into the nucleus at early S phase driven by the NLM, and assemble into empty capsids. Viral genome replication (vDNA-RF) and virions maturation occur as cells become arrested at the late S/G2 phases by the infection. Infected cells subjected to thymidine DNA replication stress (DRS), or density arrest by cell contacts (DA), interrupt drastically VPs nuclear transport, resulting into cytoplasmic empty capsids formation in MFs (B), or inefficient nuclear assembly in HFs represented by dotted capsid (C). Acronyms: C, cytoplasm; N, nucleus; NPC, nuclear pore complex.