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. 2015 Jun 11;10(6):e0127943. doi: 10.1371/journal.pone.0127943

Fig 5. Inhibition of RET reduces phosphorylation of DNA-PKcs s2056 and blocking DNA-PKcs activity increases chemosensitivity.

Fig 5

A) TT cells were treated with RPI-1 (5 μM) to inhibit RET for 24 hrs prior to nuclei isolation. Western blot analysis indicated that RET inhibition reduces DNA-PKcs s2056 phosphorylation. Total DNA-PKcs and Lamin B1 were used as loading controls. B) TT cells treated with Nu7441 (NU) (1 μM) to inhibit DNA-PKcs had a greater decrease in cell viability than DOX alone. *p ≤ 0.05, error bars = s.d.