Table 1. List of proteins found to be significantly altered in RET 9 and RET 51 lines compared to control lines.

Protein Name	RET 9	RET 51	Fold Change 9–51	Expression	Known Fxn
Nucleosome-binding protein1	9.954E-05	3.35E-06	13.07–16.29	Increased	Modifies chromatin structure for regulation of transcription and histone compaction
Isoform 1 of DNA-dependent protein kinase catalytic subunit	2.396E-05	0.006	24.14–14.04	Increased	Binds chromatin and is required for NHEJ pathway of DNA damage
Core histone macro-H2A2	0.007	0.006	6.63–6.71	Increased	Histone variant of H2A, represses transcription
Zinc finger protein 22	0.11	0.0003	6.4–5.22	Increased	Binds DNA to regulate transcription
U4/U6. U5 tri-snRNP-associated protein 1	0.02	0.02	8.24–6.58	Increased	Binds DNA and regulates RNA splicing
High mobility group protein	0.01	0.05	0.07–0.17	Decreased	Transcriptional regulator, chromatin condensation
Isoform 1 of Methyl-CpG-binding protein 3	0.001	0.001	0.18–0.18	Decreased	Recruits histone deacetylases and DNA methyltransferases
Isoform 2 of sister chromatid cohesion PDS5	0.001	0.001	0.23–0.23	Decreased	Involved in chromosome cohesion and DNA replication
Eukaryotic translation initiation factor 4E-binding protein 1	0.004	0.009	0.38–0.38	Decreased	Represses protein translation, involved in response to UV/IR
Isoform 1 of Nucleophosmin	0.0008	0.0006	0.49–0.53	Decreased	Histone assembly, cell proliferation

Fold change ≤1.5 is considered increased expression and between 0.2 and 0.6 is decreased expression.