Fig. 2. Laser-treated keratinocyte-conditioned medium (LT-KCM) induced increased melanin content and tyrosinase activity. Melan-a cells and human melanocytes were cultured in the presence of LT-KCM. The melanin contents (% of control) in both melan-a cells (A) and human melanocytes (B) are shown. Tyrosinase activity (% of control) in cultured melan-a cells (C) is shown. Data are mean±standard deviation. ^*p<0.05, ^**p<0.01; Student's t-test.