Fig. 5. Tranexamic acid (TA) reduced tyrosinase activity in melan-a cells. Melan-a cells were cultured in the presence of laser-treated keratinocyte-conditioned medium (LT-KCM). Arbutin and tranexamic acid reduced tyrosinase activity (% of control) in cultured melan-a cells. Data are mean±standard deviation. ^*p<0.05, ^**p<0.01; Student's t-test.