Table 2. Effects of Radotinib on the cell viability in patients with AML and CML.
UPN | Disease | Cell source | 0 μM | 1 μM | 10 μM | 100 μM |
---|---|---|---|---|---|---|
1 | AML | BM | 100 ± 0.0 | 69 ± 1.2 *** | 58± 1.5 *** | 57 ± 2.3 *** |
2 | AML | BM | 100 ± 0.0 | 75 ± 1.0 *** | 73 ± 0.5 *** | 68 ± 0.9 *** |
3 | AML | BM | 100 ± 0.0 | 85 ± 2.5 *** | 78 ± 2.5 *** | 65 ± 2.7 *** |
4 | AML | BM | 100 ± 0.0 | 103 ± 6.5 | 64 ± 6.2 *** | 45 ± 3.5 *** |
5 | AML | BM | 100 ± 0.0 | 95 ± 0.9 ** | 90 ± 0.9 *** | 78 ± 2.1 *** |
6 | AML | PB | 100 ± 0.0 | 91 ± 3.9 | 86 ± 6 | 87 ± 3 * |
7 | AML | PB | 100 ± 0.0 | 94 ± 0.6 ** | 90 ± 0.8 ** | 69 ± 1.8 *** |
8 | CML | BM | 100 ± 0.0 | 98 ± 7.8 | 88± 3.7 | 87 ± 6.3 |
9 | CML | BM | 100 ± 0.0 | 91 ± 5.5 | 95 ± 9.2 | 77 ± 2.9 ** |
10 | CML | BM | 100 ± 0.0 | 96 ± 0.6 | 100 ± 1 | 112 ± 2 |
11 | CML | BM | 100 ± 0.0 | 99 ± 0.8 | 102 ± 0.4 | 113 ± 1 |
12 | CML | PB | 100 ± 0.0 | 101 ± 3.2 | 98 ± 1.4 | 91 ± 5 |
These data represent the means ± SEM. Significantly different from control, 0 μM (*);
*: P < 0.05;
**: P < 0.01;
***: P < 0.001.