Table 3. Effects of Radotinib on the cell viability in AML cell lines.
| Cell lines | 0 μM | 1 μM | 10 μM | 100 μM | Karyotype |
|---|---|---|---|---|---|
| NB4 | 100 ± 0.0 | 69 ± 1.8 *** | 61 ± 2.2 *** | 18 ± 2.3 *** | t(15;17)(q22;q12) |
| HL60 | 100 ± 0.0 | 93 ± 8.6 | 84 ± 7.9 * | 52 ± 1.8 *** | Hypotetraploid |
| KASUMI-1 | 100 ± 0.0 | 45 ± 1.3 *** | 45 ± 1.5 *** | 39 ± 5 *** | t(8;21)(q22;q22) |
| THP-1 | 100 ± 0.0 | 98 ± 5 | 68 ± 2.2 *** | 46 ± 3.6 *** | t(9;11)(p22;q23) |
These data represent the means ± SEM. Significantly different from control, 0 μM (*);
***: P < 0.001;
*: P < 0.05.