Table 2.
Univariate and multivariate analyses of LMR for DFS in patients with pT3N0M0 rectal cancer
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | P value | HR (95% CI) | P value |
| CEA level | 0.470 (0.266-0.830) | 0.009 | 0.508 (0.287-0.900) | 0.021 |
| LMR | 0.790 (0.661-0.945) | 0.010 | 0.805 (0.675-0.959) | 0.015 |
| Gender | 0.506 (0.264-0.970) | 0.040 | ||
| Age | 1.026 (1.000-1.053) | 0.052 | ||
| Operation | 0.760 (0.356-1.621) | 0.477 | ||
| Tumor location | 0.731 (0.402-1.327) | 0.303 | ||
| Tumor grade | 0.939 (0.463-1.903) | 0.862 | ||
| Adjuvant treatment | 0.987 (0.531-1.835) | 0.967 | ||
Bold values are significant (P<0.05). DFS, disease-free survival; HR, hazard ratio; CI, confidence interval
The following parameters were included in the Cox proportional hazards model by backward elimination: LMR as a continuous variable, CEA level (elevated vs. normal), age as a continuous variable, gender (male vs. female), operation (APR vs. AR), tumor location (low rectal cancer vs. high rectal cancer), tumor grade (highly differentiated vs. moderately differentiated vs. poorly differentiated), and adjuvant treatment (adjuvant chemotherapy vs. no chemotherapy).