Table 1. MicroRNAs with biological activity in MPM.
| MicroRNA | Expression change in MPM vs. normal tissue |
Activity |
Experimentally validated function(s) | Reference(s) | |||
|---|---|---|---|---|---|---|---|
| Cells | Tumours | In vitro | In vivo | ||||
| miR-29c-5p | Down | N.D. | √ | Mimic inhibits growth and migration; targets DNMT1/3A | (18) | ||
| miR-31 | Down | Down | √ | Mimic inhibits growth and migration; targets PPP6C | (19,20) | ||
| Let-7a | N.D. | N.D. | √ | Induced by EphrinA1; inhibits RAS | (21) | ||
| miR-34b/c | Down | Down | √ | √ | Induced by p53 in response to cell stress; mimics inhibit MPM cell growth; inhibitors increase proliferation in mesothelial cells | (22-24) | |
| miR-15a/b | Down | Down | √ | Inhibits growth of MPM cells | (25) | ||
| miR-16 | Down | Down | √ | √ | Tumour suppressor functions; downregulates cell cycle and anti-apoptotic genes CCND1 and BCL2 | (25) | |
| miR-126 | Down | Down | √ | √ | Mimic inhibits respiration; Induced by oxidative stress; alters metabolism; targets IRS1 | (26) | |
| miR-205 | √ | Involved in EMT, affects migration; targets ZEB1 and ZEB2 | (27) | ||||
| miR-145 | Down | √ | √ | Inhibits clonogenicity and migration, sensitizes to pemetrexed; regulates OCT4 | (28) | ||
| miR-1 | N.D. | Down | √ | Growth inhibition | (29) | ||
MPM, malignant pleural mesothelioma; EMT, epithelial-to-mesenchymal transition; N.D., not determined.