Figure 3.

The essential role of A20 in the regulation of NF-κB in neurons, astrocytes and microglia. Several factors including inflammation, brain injury and stroke and toxins can induce the production and activation of NF-κB transcription factor in various cells of CNS. Activation of NF-κB, results in the induction of several inflammatory mediators as well as the activation of Ubiquitin-editing enzyme A20. A20, in turn, negatively regulates NF-κB signaling and preserves CNS-specific homeostasis.