Fig 7. The effect of blood rheological model and flow rate on the average tissue drug concentration.

Increases in bulk flow rate were found to correspond with reduced area-weighted average drug concentrations (AWAC) in the tissue. Rheological models which produced larger recirculation lengths were also found to produce lower AWAC values; however, the deviation from the AWAC obtained with the Newtonian model was observed to be less than 5% for each non-Newtonian case. It was only when modelling plasma instead of blood that any considerable deviations from the Newtonian model’s AWAC were observed and even these were only observed at ${Q^{\prime }}_{high}$.