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. 2015 Jun 15;5:10641. doi: 10.1038/srep10641

Figure 2. Three-dimensional structures of three non-synonymous EPHB4 mutations detected in lung tumor tissues.

Figure 2

For each, wild-type protein is shown in the left panel, and the mutated protein is shown in the right panel. Arrows indicate the residues of interest. All images were created with PyMOL using a crystal structure encompassing the majority of the EPHB4 TK domain (PDB 2VWY; Reference 62). Top: Glycine replaced by serine within an alpha-helix. Middle: Alanine replaced by valine between a turn and linker region. Bottom: Proline replaced by serine within a helix-turn-helix motif.