Table 1.

Emory SCC DBS for depression experience.

Subjects1

• 2080 potential subjects contacted • 524 completed phone screens • 274 medical records reviewed • 76 in-person assessments • 40 subjects enrolled ▪ 8 failed to meet pre-surgical depression severity criteria2 ▪ 1 declined surgery ▪ 1 comorbidity exclusion • N = 30 implanted ▪ 17 published in Holtzheimer et al. (2012) ▪ 11 manuscript in preparation ▪ 2 in current protocol

Standardized Assessment

• Primary outcome measure: 17 question Hamilton Depression Rating Scale (HDRS-17) ▪ Response = 50% decrease from baseline; N = 17/30 at one year ▪ Remission = 7 or less; N = 11/30 at one year

Time Course

• Clinical assessment weekly × 8 months, then tapered to semi-annual assessment by year 2 • 8 years since first subject enrolled • 1527 subject-months (127 patient-years)

¹As of 5/2015, ²HDRS-17 ≥20 averaged over 4 weeks prior to surgery.