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. 2015 Feb 17;6(9):6737–6748. doi: 10.18632/oncotarget.3253

Figure 6. Cbl-b prolonged remission and disease-specific survival in P-gp positive breast cancer patients treated with a Dox-based regimen.

Figure 6

(A) Immunohistochemistry images of tissue sections stained against Cbl-b and P-gp. a–d shows breast tissue negatively and positively stained with anti-Cbl-b antibody; e–h show breast tissue negatively and positively stained with anti-P-gp antibody. (B) Disease-specific survival rates of patients with P-gp positive breast cancer positive or negative for Cbl-b were estimated with the Kaplan–Meier method and log-rank test; n = 121, P < 0.05. (C) Proposed model showing that c-Src dependent Cav-1 phosphorylation promoted the translocation of P-gp into caveolae, resulting in MDR. In a negative feedback loop, Cbl-b translocated from the nucleus to the cytoplasm, preventing the translocation of P-gp into caveolae and reversed MDR by ubiquitinating c-Src and targeting it for degradation.