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. 2015 Feb 4;6(9):7011–7022. doi: 10.18632/oncotarget.3137

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Copyright: © 2015 Zou et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Immunoblotting hybridization showing that depletion of TNKS1BP1 blocked the autophosphorylation of DNA-PKcs/S2056 and phosphorylation of CHK2/T68 induced by IR in HeLa cells. (B) Overexpression of TNKS1BP1 induced the autophosphorylation of DNA-PKcs/S2056 in HEK-293 cells either with or without irradiation. (C) shRNA-resistant Myc-TNKS1BP1 increased the autophosphorylation level of DNA-PKcs/S2056 in TNKS1BP1-depleted HeLa-shTNKS1BP1 cells. (D) Immunofluorescence image showing the autophosphrylation of DNA-PKcs/S2056 in HeLa cells transfected and expressing EGFP-tagged TNKS1BP1 plasmid.