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. 2015 Mar 12;6(9):7244–7261. doi: 10.18632/oncotarget.3133

Figure 9. Schematic model for the function of the EGF/Arf6/ERK axis in Wnt5a expression and EMT regulation.

Figure 9

In summary, we have identified a signaling pathway that is implicated in EGF-induced gastric cancer cell EMT. EGF treatment can lead to the activation of the Arf6/ERK cascade in gastric cancer cells and contribute to P-ERK binding to Wnt5a promoter region, thereby suppressing Wnt5a expression at transcriptional level, and low Wnt5a protein expression allows EGF to induce EMT in gastric cancer cells.