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. 2015 Jan 31;6(9):7293–7304. doi: 10.18632/oncotarget.3421

Figure 5. Plexin-B2 stimulation activates small GTPases RhoA and Rac1 and synergizes with HGF in Met phosphorylation.

Figure 5

A) Sema4C-Fc stimulation for 5 min activates RhoA and Rac1 in LN229 cells measured by a G-LISA Activation Assay (Cytoskeleton) (n=3). B) Western blot analysis of Met expression in ATCC glioma cell lines and GSC (the 140 kDa band represents a processed form of Met). C) Analysis of Met phosphorylation (pMet) in LN229 cells after stimulation with SEMA4C-Fc, HGF (at sub-saturating concentration of 1 ng/ml) or both shows synergy on pMet levels.