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. 2015 Jan 31;6(9):7293–7304. doi: 10.18632/oncotarget.3421

Figure 6. Invasive glioma growth is diminished by Plexin-B2 knockdown.

Figure 6

(A-B) Representative images and quantifications of intracranial transplants of LN229 (A) and U87MG cells (B) at 2 weeks post-transplant (n=3 transplants for each cell line). Tumor cells are labeled by GFP expression (green), and microvessels by CD31 staining (red). Arrows point to cell invasions from main tumor mass. Scale bars: 500 μm (upper panels), 25 μm (lower panels). C) Intracranial transplants of SD02 GSC at 2 weeks post-transplant show close alignment and attachment of tumor cells (GFP+, green) and microvessels (CD31+, red) in control shRNA transplants (arrows). Plexin-B2 knockdown results in misalignment and reduced percentage of infiltrating tumor cells attached to microvasculature (arrowheads). Quantification is shown on the right (n=3). Scale bar: 25 μm.