Fig. 7.

Schematic illustrating the role of LAF-1 IDP motifs and RNA in droplet assembly and properties. IDP motifs (red) in LAF-1 (green) and likely other P granule proteins (blue) are important for driving phase separation into dynamic but coherent liquid droplets. These droplets are a liquid phase but with relatively high viscosity. RNA gives rise to dynamic interactions with LAF-1 (and likely other) IDP domains, modulating IDP–IDP interactions and leading to decreased droplet viscosity and increased molecular dynamics within the droplet.