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Sorafenib and SC-1 treatment induce apoptosis of HSCs via the STAT3 pathway. (A) Dose-escalation and time-dependent effects of sorafenib and SC-1 for 24 or 48 h on cell viability in HSC-T6, LX2, and mouse primary HSCs. Circles, mean; bars, SE (n = 3). (B) Dose-escalation effects of sorafenib and SC-1 for 24 h on apoptosis in HSC-T6 and LX2 cells. Columns, mean; bars, SE (n = 3). (C) Dose-escalation effects of sorafenib or SC-1 for 24 h on STAT3-related proteins in HSC-T6 and LX2 cells.
