NEUROSCIENCE Correction for “Ikaros promotes early-born neuronal fates in the cerebral cortex,” by Jessica M. Alsiö, Basile Tarchini, Michel Cayouette, and Frederick J. Livesey, which appeared in issue 8, February 19, 2013, of Proc Natl Acad Sci USA (110:E716–E725; first published February 4, 2013; 10.1073/pnas.1215707110).
The authors note that Fig. 6 appeared incorrectly. Specifically, the panels in Fig. 6A and 6E representing lateral and medial cerebral cortex, respectively, in the P0 (neonatal) D6-Ikaros transgenic mouse (D6-Ik) are overlapping images of the same region of a tissue section. The authors note that the wrong panel was introduced during preparation of a revised manuscript. The corrected figure and its legend appear below.
Fig. 6.
Early and sustained increase in deep layer genesis and delayed upper layer genesis following sustained Ikaros expression in the cortex. (A–D) Immunostaining and quantifications of Tbr1 (layer 6, red), Ctip2 (weak in layer 6 and strong in layer 5, green), and Satb2 (layers 2–4; blue) in WT and D6-Ikaros lateral cortex at different stages of cortical development as indicated. (E–H) Immunostaining and quantifications of the same markers in WT and D6-Ikaros medial cortex. Increased numbers of Tbr1+ and Ctip2+ deep layer neurons were observed in D6-Ikaros compared with WT littermates throughout development both laterally and medially, as well as a delayed appearance and decreased numbers of Satb2+ upper layer neurons throughout development. In B–D and F–H, values represent mean ± SEM (n = 3–7 brains). *P < 0.05; **P < 0.01; ***P < 0.001. (Scale bars: 50 μm.)