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Loss of Bok protects mice from ER stress-induced apoptosis. (A) Representative Western blot analysis (n = 3) for the ER stress response pathway and activated caspase-3. (B) Immunofluorescence detection of CHOP, activated caspase-3, and TUNEL in WT and Bok−/− livers (n = 3) from a representative mouse treated with vehicle, 1 mg/kg TG, or 10 mg/kg ETOP. Merge is between red (CHOP in rows 1 and 2; cleaved caspase-3 in rows 3 and 4) and blue (TO-PRO3).
