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Comparison of selected PK parameters among VEGF inhibitors
| Inhibitor | pI | Dose (mg/kg) | Cmax(μg/ml) | AUC (μg · days/ml) | Reference |
|---|---|---|---|---|---|
| HB-002.1 | 6.7 | 2.5 | 20.3 | 81.46 | This study |
| Bevacizumab | 7.6 | 9.3 | 74.1 | 682 | 39 |
| Parental VEGF-Trap | 9.4 | 4.0 | 0.05 | 0.04 | 24 |
| VEGF-TRAP∆B1 | 9.1 | 4.0 | 1.3 | 1.36 | 24 |
| VEGF-TRAP∆B2 | 8.9 | 4.0 | 2.65 | 5.42 | 24 |
| Aflibercept | 8.82 | 4.0 | 16 | 36.28 | 24 |
