Table 1.
Comparison of existing DCE-MRI packages*
| Software package | Language | Operating system | License | Models included | Fitting | Other MRI-relevant features | Input/output | Location |
|---|---|---|---|---|---|---|---|---|
| dcemriS4 | R | Linux, Windows, Mac OS | BSD | - Standard Kelty- Single-compartment model- Extended Kety | - Non-linear least squares- Bayesian estimation | - motion correction and co-registration - B1 mapping - T1 mapping - AIF fitting - DWI fitting - Pixel processing - Job report for later retreival - Access to R functions | - DICOM - NIFTI - Raw data | http://dcemri.sourceforge.net |
| dcetool | C, Plugin for ClearCanvas | Windows | Proprietary | - Tofts - Adiabatic tissue homogeniety - Thorwarth- Extended Tofts - Semi-quantitative metrics (Slope/AUC) | Proprietary | - DICOM - Raw data | http://thedcetool.com/ | |
| PMI | IDL | Windows | GNU GPL | - Uptake models - Steady-state - Patlak - Model-free deconvolution - Tofts- Extended Tofts - 2CXM - 2C filtration model for kidney - Dual-inlet models for Liver - Semi-quantitative metrics (Slope/Signal enhancement) | - Non-linear Least squares - Truncated singular value decomposition | - ROI and pixel processing - AIF/time series visualization/editing - Access to IDL functions | - DICOM - Raw data | https://sites.google.com/site/plaresmedima/ |
| UMMPerfusion | C, OsiriX plugin | Mac OS | BSD | - Model free deconvolution | - Truncated singular value decomposition | - ROI and pixel processing - Job report for later retreival - AIF/time series visualization/editing | - DICOM | http://ikrsrv1.medma.uni-heidelberg.de/redmine/projects/ummperfusion |
| Pydcemri | Python | Linux, Windows, Mac OS | GNU GPL | - Tofts - Extended Tofts | - Non-linear Least squares | - Access to python functions | - Raw data | https://github.com/welcheb/pydcemri |
| DCEMRI.jl | Julia | Linux, Windows, Mac OS | MIT | - Tofts - Extended Tofts - Plasma only | - Non-linear Least squares | - ROI and pixel processing - T1 mapping - Batch processing - Access to Julia functions | - Matlab data | https://github.com/davidssmith/DCEMRI.jl |
| DCE@UrLAB | IDL | Windows | BSD | - Tofts - Hoffmann - Larsson - Fast exchange limit reference region | - Non-linear Least squares | - ROI and pixel processing - Access to IDL functions | - DICOM - Bruker - Raw data | http://www2.die.upm.es/im/archives/DCEurLAB/ |
| DATforDCEMRI | R | Creative Commons | - Tofts - Semi-quantitative metrics (AUC, MRT - mean residence time) | - Numerical deconvolution | - Pixel processing - Access to R functions | - R readable data formats | https://github.com/cran/DATforDCEMRI | |
| TOPPCAT | Javascript, ImageJ plugin | Linux, Windows, Mac OS | BSD | - Patlak | - Non-linear Least squares | - T1 mapping - Access to ImageJ functions | - ImageJ readable data formats | https://dblab.duhs.duke.edu/modules/dblabs_topcat/ |
| Jim | Java | Linux, Windows, Mac OS | Proprietary | - Tofts - Extended Tofts - One compartment - Fermi - 2CXM - Semi-quantitative metrics (AUC) | Proprietary | - ROI and pixel processing | - DICOM - Analyze - Bruker - Commercial formats - Raw data | http://www.xinapse.com/Manual/index.html |
| PermGUI | Matlab | Windows | Creative Commons | - Patlak | - T1 mapping - ROI and pixel processing | - DICOM - Analyze - NIFTI | http://www.quantilyze.com/permgui/ | |
| BioMap | IDL | Linux, Windows, Mac OS | Proprietary | - Extended Tofts | - Non-linear Least squares | - T1 fitting | - DICOM - Analyze - TIF/PNG | http://www.maldi-msi.org/ |
| ROCKETSHIP | Matlab | Linux, Windows, Mac OS | GNU GPL | - Tofts - Extended Tofts - Fast exchange regime (FXR) - 2CXM - Tissue uptake - Nested-model selection - Patlak - Semi-quantitative metrics (AUC) | - Non-linear Least squares | - T1 mapping - ROI and pixel processing - AIF fitting/import - DWI fitting - Job report for later retreival - AIF/time series visualization/editing - Batch processing - Access to Matlab functions - Model fit comparisons with statistical metrics - Drift correction | - DICOM - Analyze - NIFTI - Raw data - Matlab data | https://github.com/petmri/ROCKETSHIP |
*Excludes commerical packages for clinical use, AUC: area under curve, DWI: diffusion-weighted imaging