Table 2.

Fitting parameters for simulation studies

Generating model	Fitting model	Acquistion duration (min)	Time resolution (s)	SNR	Ktrans (1/min)	ve	vp	Fp (1/min)	τi (s)
Patlak	Patlak	10	0.5, 6	5, 100	0.01, 0.02, 0.05, 0.1, 0.2, 0.35	N/A	0.001, 0.005 0.01 0.02 0.05 0.1	N/A	N/A
Tofts	Tofts	10	0.5, 6	5, 100	0.01, 0.02, 0.05, 0.1, 0.2, 0.35	0.01, 0.02, 0.05, 0.1, 0.2, 0.5	N/A	N/A	N/A
Ex-Tofts	Ex-Tofts	10	0.5, 6	5, 100	0.01, 0.02, 0.05, 0.1, 0.2, 0.35	0.01, 0.02, 0.05, 0.1, 0.2, 0.5	0.001, 0.005 0.01 0.02 0.05 0.1	N/A	N/A
2CXM	2CXM	10	0.5, 6	5, 100	0.01, 0.02, 0.05, 0.1, 0.2, 0.35	0.01, 0.02, 0.05, 0.1, 0.2, 0.5	0.001, 0.005 0.01 0.02 0.05 0.1	0.5, 1, 5	N/A
Tissue uptake	Tissue uptake	10	0.5, 6	5, 100	0.01, 0.02, 0.05, 0.1, 0.2, 0.35	N/A	0.001, 0.005 0.01 0.02 0.05 0.1	0.5, 1, 5	N/A
FXR	FXR	10	0.5, 6	5, 100	0.01, 0.02, 0.05, 0.1, 0.2, 0.35	0.01, 0.02, 0.05, 0.1, 0.2, 0.5	N/A	N/A	0.1, 0.5, 2
Steady-state	Nested	10	0.5	5, 100	N/A	N/A	0.005, 0.1	N/A	N/A
Patlak	Nested	10	0.5	5, 100	0.01, 0.35	N/A	0.005, 0.1	N/A	N/A
Ex-Tofts	Nested	10	0.5	5, 100	0.01, 0.35	0.01, 0.1	0.005, 0.1	N/A	N/A