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. 2015 Jun 15;5:11231. doi: 10.1038/srep11231

Figure 4. Increase of proinflammatory mediator production by IGFBP-3.

Figure 4

(A) After 1 h reperfusion, mRNA levels of TNF-α, IL-1β, ICAM-1, IL-8, and CXCL2 in liver tissues were analyzed by real-time RT-PCR. (B) After 6 h reperfusion, serum levels of TNF-α, and IL-1β were measured using ELISA. Values are the mean±SEM (n = 9 mice per group). *,  p< 0.05 and **, p < 0.01 versus sham-operated mice; #, p < 0.05 and ##, p < 0.01 versus AdLacZ-injected mice.