Table 3.
Logistic regression analysis of factors associated with bilateral mastectomy in patients with unilateral breast cancer
| Characteristics | Univariate (Unadjusted) | Multivariate (Adjusted) | ||
|---|---|---|---|---|
|
|
|
|||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age (per year) | 0.941 (0.909, 0.074) | 0.001* | 0.942 (0.912, 0.973) | <0.001* |
| Menstruation | ||||
| pre-menopausal | 1.000 | |||
| post-menopausal | 0.833 (0.282, 2.427) | 0.737 | ||
| BMI | ||||
| <25 | 1.000 | |||
| ≥25 | 1.648 (0.811, 3.348) | 0.167 | ||
| Clinical tumor stage | ||||
| T<5 cm | 1.000 | |||
| T≥5 cm | 0.690 (0.234, 2.032) | 0.500 | ||
| Pathological tumor stage | ||||
| T<5 cm | 1.000 | |||
| T≥5 cm | 0,925 (0.394, 2.169) | 0.875 | ||
| Pathological lymph node status | ||||
| Negative | 1.000 | 1.000 | ||
| Positive | 0.071 (0.029, 0.175) | <0.001* | 0.072 (0.030, 0.174) | <0.001* |
| Histological grade | ||||
| MBRS≤5 | 1.000 | |||
| MBRS≥6 | 0.607 (0.253, 1.455) | 0.263 | ||
| LVI | ||||
| No | 1.000 | |||
| Yes | 0.755 (0.359, 1.585) | 0.457 | ||
| ER status | ||||
| Negative | 1.000 | |||
| Positive | 0.805 (0.344, 1.879) | 0.615 | ||
| PR status | ||||
| Negative | 1.000 | |||
| Positive | 1.406 (0.553, 3.576) | 0.475 | ||
| HER-2 expression | ||||
| Negative | 1.000 | |||
| Positive | 1.592 (0.654, 3.879) | 0.306 | ||
| Ki-67 index | ||||
| Low | 1.000 | |||
| High | 0.738 (0.334, 1.634) | 0.454 | ||
| Multiple biopsy | ||||
| No | 1.000 | |||
| Yes | 2.418 (0.553, 10.575) | 0.241 | ||
| History of augmentation | ||||
| No | 1.000 | |||
| Yes | 6.347 (0.984, 40.936) | 0.052 | ||
| Nodal surgery | ||||
| SLNB | 1.000 | 1.000 | ||
| ALND | 0.276 (0.115, 0.663) | 0.004* | 0.274 (0.116, 0.646) | 0.003* |
| MRI within 6 months before the surgery | ||||
| No | 1.000 | |||
| Yes | 1.549 (0.699, 3.432) | 0.281 | ||
| BRCA mutation | ||||
| No | 1.000 | |||
| Yes | 4.508 (0.837, 24.275) | 0.080 | ||
| Family history | ||||
| No | 1.000 | 1.000 | ||
| Yes | 3.439 (1.726, 6.854) | <0.001* | 4.042 (2.082, 7.847) | <0.001* |
| Reconstruction | ||||
| No | 1.000 | |||
| Yes | <0.001 | 0.999 | ||
| Type of reconstruction | ||||
| None | 1.000 | <0.001* | 1.000 | <0.001* |
| Tissue expanders/implants | 4.323 (1.794, 10.416) | 0.001* | 4.952 (2.125, 11.539) | <0.001* |
| Autologous flaps | 0.739 (0.315, 1.732) | 0.486 | 0.746 (0.329, 1.691) | 0.482 |
| Both | 1.152 (0.043, 31.052) | 0.933 | 1.522 (0.067, 34.809) | 0.792 |
| Neo-adjuvant chemotherapy | ||||
| No | 1.000 | |||
| Yes | 0.453 (0.193, 1.062) | 0.069 | ||
MBRS: Modified Bloom Richardson score; LVI: lymphatic vessel invasion; ER: Estrogen receptor; PR: Progesterone receptor; OR: odds ratio; 95% CI: 95% confidence interval;
*
P value less than 0.05.