Table 1.

Correlation of clinicopathological characteristics with LOXL4 expression

Variable	LOXL4 protein level (n=298)
	LOXL4Low	LOXL4High	P value†
Age (years)
≤ 51 yr	74	61	0.910
> 51 yr	98	83
Sex
Male	24	14	0.299
Female	148	130
γ-GT (units/L)
≤ 54	73	70	0.307
> 54	99	74
AFP (ng/ml)
≤ 20	66	61	0.491
> 20	106	83
HBsAg
Negative	37	25	0.395
Positive	135	119
Liver cirrhosis
No	32	18	0.164
Yes	140	126
Microvascular invasion
absence	120	98	0.807
present	52	46
Tumor size
≤ 5 cm	106	102	0.096
> 5 cm	66	42
Tumor differentiation
I+II	125	104	1.000
III+IV	47	40
Multinodular tumor
Single	149	118	0.277
Multiple	23	26
Tumor encapsulation
Complete	86	77	0.573
None	86	67
TNM stage
I-II	110	80	0.135
III-IV	62	64
BCLC stage
A	94	91	0.137
B, C	78	53

Abbreviations: HBsAg, hepatitis B surface antigen; AFP, α-fetoprotein; γ-GT, γ-glutamyl transferase; TNM, tumor-nodes-metastasis; *Serum samples obtained from patients were used for ELISA validation.

^†A P-value < 0.05 was considered statistically significant.

P-values were calculated using the Pearson chi-square test.