Table 2.
Univariate and multivariate analyses of prognostic factors associated with survival
| Variables | OS | |||
|---|---|---|---|---|
|
| ||||
| Univariate | Multivariate | |||
|
| ||||
| P value | P value | HR | 95% CI | |
| TMA assays (n=298) | ||||
| Sex (female vs. male) | 0.704 | NA | ||
| Age, years (≤ 50 vs. > 50) | 0.917 | NA | ||
| HBsAg (negative vs. positive) | 0.093 | NS | ||
| AFP, ng/ml (≤ 20 vs. > 20) | 0.009 | NS | ||
| γ-GT, U/L (≤ 54 vs. > 54) | 0.006 | NS | ||
| Liver cirrhosis (no vs. yes) | 0.991 | NA | ||
| Tumor size, cm (≤ 5 vs. > 5) | 0.000 | 0.000 | 3.542 | 2.437~5.149 |
| Tumor number (single vs. multiple) | 0.189 | 0.005 | 1.916 | 1.221~3.007 |
| Encapsulation (complete vs. none) | 0.078 | NA | ||
| Microvascular invasion (no vs. yes) | 0.001 | NS | ||
| Tumor differentiation (I-II vs. III-IV) | 0.012 | 0.014 | 1.598 | 1.100~2.321 |
| TNM stage (I vs. II III) | 0.001 | NS | ||
| LOXL4 (Low vs. High) | 0.001 | 0.003 | 0.568 | 0.392~0.823 |
Abbreviations: OS, overall survival; AFP: α-fetoprotein; γ-GT, γ-glutamyl transferase; TNM, tumor-nodes-metastasis; HR, hazard ratio; CI, confidential interval; NA, not adopted. Boldface type indicates significant values. †Cox proportional hazards regression. a. Degree of freedom reduced because of constant or linearly dependent covariates.