Table 4.
Comparative analysis between the studied minerals with some prognostic factors in the breast cancer group
| 25-OH Vit D3 (20-40 ng/ml) | Total Calcium (2.2-2.7 mmol/L) | Ionized calcium (1.15-1.35 mmol/L) | Parathormone (10-70 pg/ml) | Mg (1.8-2.6 mg/dl) | Phos (2.5-4.5 mg/dl) | Ca:Mg ratio (3.1-1) | Ca:P ratio (2.63:1) | ||
|---|---|---|---|---|---|---|---|---|---|
| LN involvement | Yes (N=47) | 17.5 (9.3-22.8) | 2.2 (2-2.4) | 1.1 (1-1.15) | 55.9 (42.2-81.2) | 1.8 (1.6-2.1) | 3.6 (3.1-4.1) | 1.2 (0.94-1.4) | 0.58 (0.49-0.83) |
| No (N=51) | 15.4 (8.9-30.4) | 2.2 (1.8-2.3) | 1 (0.9-1.1) | 61.2 (42.3-98.7) | 1.7 (1.5-2.1) | 3.9 (3.4-4.4) | 1.2 (0.9-1.5) | 0.55 (0.44-0.64) | |
| P-value | 0.895 | 0.559 | 0.019* | 0.569 | 0.605 | 0.064 | 0.795 | 0.121 | |
| Presence of metastasis | Yes (N=16) | 16.7 (11-22) | 2 (1.9-2.2) | 1.04 (0.98-1.08) | 44 (34-63) | 1.8 (1.6-2.1) | 3.8 (3.5-4.4) | 1 (0.9-1.3) | 0.57 (0.49-0.74) |
| No (N=82) | 14.6 (8.7-24.5) | 2.2 (1.9-2.3) | 1 (0.9-1.1) | 60.4 (42-90) | 1.8 (1.5-2.1) | 3.8 (3.1-4.3) | 1.2 (0.95-1.5) | 0.52 (0.44-0.63) | |
| P-value | 0.624 | 0.089 | 0.942 | 0.034* | 0.877 | 0.44 | 0.452 | 0.163 | |
| Grade | Grade 2 (N=89) | 14.6 (8.8-25) | 2.2 (1.9-2.3) | 1.05 (0.9-1.1) | 58.6 (39.8-87.9) | 1.8 (1.6-2.1) | 3.7 (3.2-4.3) | 1.2 (0.92-1.4) | 0.56 (0.46-0.68) |
| Grade 1&3 (N=9) | 16 (8-20) | 2.2 (2-2.3) | 1.09 (0.96-1.1) | 57 (48-72) | 1.5 (1.4-1.9) | 4 (3.3-4.5) | 1.5 (1.1-1.7) | 0.53 (0.48-0.70) | |
| P-value | 0.854 | 0.916 | 0.815 | 0.936 | 0.077 | 0.794 | 0.178 | 0.85 | |
| Menopausal status | Premenopause (N=36) | 16.4 (8.9-23.4) | 2.3 (2-2.4) | 1 (1-1.1) | 57 (43-88) | 1.7 (1.5-2.1) | 3.7 (3.3-4.4) | 1.3 (0.95-1.5) | 0.58 (0.50-0.65) |
| Postmenopause (N=62) | 14.7 (8.5-24) | 2.2 (1.9-2.3) | 1 (0.9-1.1) | 58 (38-80) | 1.9 (1.6-2.1) | 3.8 (3.1-4.3) | 1.2 (0.9-1.4) | 0.54 (0.46-0.71) | |
| P-value | 0.900 | 0.236 | 0.587 | 0.87 | 0.35 | 0.456 | 0.245 | 0.614 | |
| Pathological type | IDC (N=83) | 14.6 (8.7-24) | 2.2 (1.9-2.3) | 1 (0.95-1.1) | 58 (41-87) | 1.8 (1.5-2.1) | 3.6 (3.1-4.3) | 1.2 (0.9-1.4) | 0.56 (0.47-0.70) |
| Other types (N=15) | 17.5 (10-31) | 2.1 (1.9-2.4) | 1 (0.93-1.1) | 58.4 (38-78) | 1.7 (1.5-1.9) | 4 (3.6-4.5) | 1.2 (1-1.5) | 0.52 (0.46-0.59) | |
| P-value | 0.474 | 0.992 | 0.628 | 0.79 | 0.642 | 0.186 | 0.746 | 0.291 | |
| ER | Positive (N=55) | 14.5 (8.5-22) | 2.2 (1.9-2.3) | 1 (0.95-1.1) | 55 (37-90) | 1.8 (1.6-2.1) | 3.8 (1-0.15) | 1.2 (0.95-1.4) | 0.58 (0.45-0.66) |
| Negative (N=43) | 18 (9-36) | 2.2 (2-2.3) | 1 (0.94-1.1) | 63 (44-83) | 1.7 (1.5-2.1) | 3.7(1-0.15) | 1.2 (0.9-1.8) | 0.55 (0.49-0.72) | |
| P-value | 0.120 | 0.718 | 0.747 | 0.413 | 0.620 | 0.846 | 0.447 | 0.728 | |
| PR | Positive (N=49) | 13 (7.5-20) | 2.2 (2-2.3) | 1 (0.96-1.1) | 57 (38-88) | 1.7 (1.5-2.1) | 3.6 (3.3-4.3) | 1.2 (0.95-1.4) | 0.58 (0.48-0.68) |
| Negative (N=49) | 18 (9-32) | 2.2 (1.9-2.3) | 1 (0.93-1.1) | 60 (43-85) | 1.8 (1.6-2.1) | 3.8 (3.2-4.3) | 1.2 (0.9-1.5) | 0.55 (0.47-0.58) | |
| P-value | 0.048* | 0.761 | 0.809 | 0.765 | 0.792 | 0.508 | 0.534 | 0.854 |
*
Significant.
Median and interquartile range in parenthesis. LN: Lymph node. IDC, Invasive duct carcinoma; Mg, Magnesium; Phos, Phosphorus; ER, Estrogen receptor; PR, Progesterone receptor.