Table 1.
Clinical description and outcome of EBOV-challenged NHPs
| Subject No. |
Sex | Group | Clinical illness | Clinical pathology |
|---|---|---|---|---|
| 0805068 | M | Untreated Control | Fever (d6); mild depression (d6–7); severe depression (d8); lethargy (d7–8); loss of appetite (d6–8); mild petechial rash (d8); rectorrhagia (d8); hunched posture (d6,7,8 am); recumbency (d8 pm); Animal euthanized in pm on d8 | Leukocytosis (d6,8); granulocytosis (d3,6,8); thrombocytopenia (d6,8); lymphopenia (d3,6,8); ALT >10-fold ↑ (d8); AST >4-fold ↑ (d6); AST >10-fold ↑ (d8); ALP >2-fold ↑ (d6); ALP >8-fold ↑ (d8); GGT >10-fold ↑ (d8); BUN >8-fold ↑ (d8); CRE 7-fold ↑ (d8); CRP >10-fold ↑ (d6,8); fibrinogen >2-fold ↑ (d6) |
| 1105274 | F | Untreated Control | Fever (d6–7), mild depression (d8); severe depression (d9); lethargy (d8–9); loss of appetite (d8–9); mild petechial rash (d9); diarrhea (d9); hunched posture (d9 am); recumbency (d9 pm); Animal euthanized in pm on d9 | Leukocytosis (d6); granulocytosis (d6); thrombocytopenia (d9); ALT >6-fold ↑(d9); AST >10-fold ↑ (d9); BUN >2-fold ↑ (d9); CRP >10-fold (d6); 4-fold ↑ (d9); APTT >2-fold ↑ (d9); fibrinogen >2-fold ↑ (d6) |
| JE60 | M | Untreated Control | Fever (d6), mild to moderate depression (d6–8); severe depression (d9); lethargy (d7–9); loss of appetite (d6–9); mild petechial rash (d6–9); severe epistaxis (d9); diarrhea (d9); hunched posture (d6–8); recumbency (d9); Animal euthanized in am on d9 | Thrombocytopenia (d6,9); lymphopenia (d6,9); hypoalbuminemia (d9); hypoproteinemia (d9); AST >6-fold ↑ (d9); BUN >2-fold ↑ (d9); CRP >10-fold (d6); 4-fold ↑ (d9); APTT >2-fold ↑ (d9) |
| 0902056 | F | 72 h Delay to treat | Fever (d8–10); mild depression (d8–12); loss of appetite (d5–13); mild petechial rash (d9–15); Animal survived | Leukocytosis (d10); granulocytosis (d6,10); thrombocytopenia (d6,10,14); lymphopenia (d6); ALT >2-fold ↑(d6,10); AST >4-fold ↑ (d6); AST >10-fold ↑ (d10); GGT >2-fold↑ (d10); CRP > 10-fold ↑ (d6,10); fibrinogen >2-fold ↑ (d6) |
| 1005445 | M | 72 h Delay to treat | Mild depression (d8–12); loss of appetite (d5–14); mild petechial rash (d9–13); Animal survived | Granulocytosis (d10); Thrombocytopenia (d6,10); lymphopenia (d6); ALT >10-fold ↑ (d6); ALT >5-fold ↑ (d10); AST >10-fold ↑ (d6,10); CRP > 10-fold ↑ (d6,10); APTT >3-fold ↑ (10) |
| 1006241 | M | 72 h Delay to treat | Fever (d5–7); mild depression (d8–11); loss of appetite (d7–14); Animal survived | Leukocytosis (d6,14); granulocytosis (d6,14); AST >7-fold ↑ (d10); CRP > 10-fold ↑ (d6,10) fibrinogen >2-fold ↑ (d6) |
a
Days after EBOV challenge are in parentheses. Fever is defined as a temperature more than 2.5°F over baseline or at least 1.5°F over baseline and ≥103.5°F. Mild rash: focal areas of petechiae covering less than 10% of the skin. Lymphopenia and thrombocytopenia are defined by a ≥40% drop in numbers of lymphocytes and platelets, respectively. Leukocytosis and granulocytosis are defined by ≥40% increase in numbers of white blood cells. (ALP) alkaline phosphatase, (ALT) alanine aminotransferase, (AST) aspartate aminotransferase, (APTT) activated partial thromboplastin time, (BUN) blood urea nitrogen, (CRE) creatinine, (CRP) C-reactive protein, (GGT) gamma glutamyltransferase.