Table 7.

Confirmed and likely nanomedicine products identified, which exhibit active behavior, beyond active targeting.

Use	Application(s)/Product(s)	Company	Status	Nanocomponent	Active Mechanism
Solid Tumor Hyperthermia	NanoTherm [57]	MagForce Nanotechnologies AG	Approved	Iron-Oxide Nanoparticles	AC Magnetic Heating
	Targeted Nano-Therapeutics [107]	Aspen Medisys, LLC. (Formerly Triton BioSystems, Inc.)	Pre-Clinical	Iron-Oxide Nanoparticles	AC Magnetic Heating
	AuroShell [64]	Nanospectra Biosciences	Phase I	Gold Nanoshell	IR Laser Heating
Solid Tumor Treatment	NanoXray [57]	Nanobiotix	Phase I	Proprietary Nanoparticle	X-Ray Induced Electron Emission
In Vivo Imaging	Feridex IV, Gastromark Combidex (Ferumoxtran-10) [80,108]	Advanced Magnetics	Approved (1996) Phase III	Iron-Oxide Nanoparticles	Enhanced MRI Contrast
	Endorem, Lumirem, Sinerem [80,108]	Guebert	Approved / Investigational	Iron-Oxide Nanoparticles	Enhanced MRI Contrast
	FeraSpin [109]	Miltenyi Biotec	Research Use Only	Iron-Oxide Nanoparticles	Enhanced MRI Contrast
	Clariscan [59]	Nycomed	Phase III	Iron-Oxide Nanoparticles	Enhanced MRI Contrast
	Resovist [80,108] Supravist [60]	Schering	Approved (2001) Phase III	Iron-Oxide Nanoparticles	Enhanced MRI Contrast
In Vitro Imaging	Qdot Nanocrystals [110]	Invitrogen Corporation	Research Use Only	Quantum Dot	Fluorescent Emission
	Nanodots [111]	Nanoco Group PLC	Research Use Only	Quantum Dot	Fluorescent Emission
	TriLite™ Nanocrystals [112]	Crystalplex Corporation	Research Use Only	Quantum Dot	Fluorescent Emission
	eFluor Nanocrystals [113]	eBiosciences	Research Use Only	Quantum Dot	Fluorescent Emission
	NanoHC [114]	DiagNano	Investigational (Research Only)	Quantum Dot	Fluorescent Emission
In Vitro Cell Separation	CellSearch® Epithelial Cell Kit [101]	Veridex, LLC (Johnson & Johnson)	Approved (2004)	Iron-Oxide Nanoparticles	Magnetic Separation
	NanoDX [115]	T2 Biosystems	Research Use Only	Iron-Oxide Nanoparticles	Magnetic Separation