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. 2015 Feb 10;6(7):4585–4601. doi: 10.18632/oncotarget.3278

Table 1. Ribosomal-related Proteins Up-regulated in MCF7 Mammospheres.

Symbol Gene Description Fold-Upregulation ANOVA
Small Subunit (14)
RPS9 40S ribosomal protein S9 Infinity 0.025
RPS3A 40S ribosomal protein S3A 582.09 1.12E-08
RPS27A 40S ribosomal protein S27A 32.14 0.0002
RPS3 40S ribosomal protein S3 28.39 6.36E-07
RPS23 40S ribosomal protein S23 19.85 5.84E-09
RPS20 40S ribosomal protein S20 7.55 2.73E-06
RPS7 40S ribosomal protein S7 6.85 4.56E-05
RPS21 40S ribosomal protein S21 5.74 0.006
RPS6 40S ribosomal protein S6 3.88 0.009
RPS4X 40S ribosomal protein S4, X-linked 3.69 0.02
RPS7 40S ribosomal protein S7 3.31 3.70E-07
RPS29 40S ribosomal protein S29 2.38 0.001
RPS9 40S ribosomal protein S9 2.03 0.002
RPS7 40S ribosomal protein S7 2.01 0.01
Large Subunit (21)
RPL23A 60S ribosomal protein L23A 265.34 1.17E-10
RPLP0 60S acidic ribosomal protein P0 144.75 1.11E-05
RPL14 60S ribosomal protein L14 119.42 4.50E-09
RPL32 60S ribosomal protein L32 55.04 3.22E-08
RPL19 60S ribosomal protein L19 42.89 2.97E-09
RPL36 60S ribosomal protein L36 38.80 0.0002
RPL10 60S ribosomal protein L10 32.94 2.22E-07
RPL3 60S ribosomal protein L3 32.87 6.64E-06
RPL18A 60S ribosomal protein L18A 20.49 4.24E-11
RPL37A 60S ribosomal protein L37A 17.12 8.28E-07
RPL8 60S ribosomal protein L8 10.68 8.89E-06
RPL7 60S ribosomal protein L7 8.47 5.75E-08
RPL17 60S ribosomal protein L17 5.19 1.09E-06
RPL36AL 60S ribosomal protein L36A-like 3.59 0.0001
RPL5 60S ribosomal protein L5 3.56 0.0005
RPL6 60S ribosomal protein L6 3.00 4.91E-06
RPL12 60S ribosomal protein L12 2.91 0.002
RPL27 60S ribosomal protein L27 2.73 0.02
RPL9 60S ribosomal protein L9 2.18 0.01
RPL27A 60S ribosomal protein L27A 1.91 0.025
Ribosomal S6 kinase (1)
RPS6KB1 Ribosomal protein S6 kinase, 70kDa, polypeptide 1 14.97 4.92E-09
Mitochondrial Ribosomal Proteins (2)
MRPL45 39S ribosomal protein L45, mitochondrial 46.42 4.32E-11
MRPL17 39S ribosomal protein L17, mitochondrial 4.80 5.31E-05
Translation initiation factors (required for mRNA binding to ribosomes) (7)
EIF4A1 Eukaryotic translation initiation factor 4A-I 439.74 4.07E-07
EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 317.87 7.60E-09
EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 66.29 2.02E-07
EIF5A2 Eukaryotic translation initiation factor 5A-2 37.14 2.49E-07
EIF3H Eukaryotic translation initiation factor 3 subunit H 8.45 1.99E-06
EIF6 Eukaryotic translation initiation factor 6 5.23 2.74E-06
EIF3B Eukaryotic translation initiation factor 3 subunit B (EIF3S9) 1.91 0.003
Elongation factors (promote delivery of aminoacyl tRNAs to the ribosome) (8)
EEF1D Elongation factor 1 delta Infinity 1.41E-10
GFM1 Mitochondrial elongation factor G 97.22 1.32E-05
EEF1G Elongation factor 1 gamma 17.00 0.008
EEF2 Elongation factor 2 15.67 0.03
EEF1A1 Elongation factor 1 alpha 7.56 9.90E-08
TSFM Elongation factor Ts, mitochondrial 3.75 0.002
EEF1A2 Elongation factor 1-alpha 2 2.87 0.0002
TUFM Elongation factor Tu, mitochondrial 2.31 0.0008
Enzymes for tRNA Synthesis (18)
VARS Valine--tRNA ligase Infinity 3.38E-11
TRMT112 tRNA methyltransferase 112 362.30 3.19E-10
WARS Tryptophan--tRNA ligase, cytoplasmic 272.93 2.51E-09
RARS Arginine--tRNA ligase, cytoplasmic 154.98 2.70E-10
YARS Tyrosine--tRNA ligase, cytoplasmic 77.20 1.90E-12
EPRS Bifunctional-tRNA ligase (Glutamate and Proline) 60.55 1.60E-09
FARSA Phenylalanine--tRNA ligase alpha 53.34 2.11E-08
AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 20.28 0.0007
HARS2 Histidine--tRNA ligase, mitochondrial 13.05 4.16E-07
MARS methionine-tRNA synthetase 6.77 7.67E-08
LARS Leucine--tRNA ligase, cytoplasmic 6.63 6.99E-05
TARS Threonyl-tRNA synthetase 6.34 0.001
RTCB tRNA-splicing ligase (C22orf28) 3.52 2.05E-09
SARS Serine--tRNA ligase, cytoplasmic 2.79 6.95E-06
NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 2.37 0.026
DARS Aspartate--tRNA ligase, cytoplasmic 2.10 0.0009
GARS Glycine--tRNA ligase 1.81 0.0003
AARS Alanine--tRNA ligase, cytoplasmic 1.47 0.002
Amino Acid Transporters (1)
SLC7A5 Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 5 2.85 5.77E-06