Table 6. Heat Shock Proteins Over-Expressed in Mammospheres are also Transcriptionally Up-regulated in Human Breast Cancer Cells In Vivo (Cancer Epithelia vs. Tumor Stroma).
| Symbol | Gene Description | Fold-Upregulation (Epithelial/Stromal) | P-value |
|---|---|---|---|
| (Epithelial/Stromal) | |||
| HSP90AB1 | Heat shock protein HSP 90-beta | 4.94 | 4.03E-06 |
| HSP90AA1 | Heat shock protein HSP 90-alpha | 3.76 | 2.12E-04 |
| HSPA4 | Heat shock 70 kDa protein 4 | 3.75 | 2.18E-04 |
| HSPA9 | Stress-70 protein, mitochondrial | 3.69 | 2.64E-04 |
| HSPB1 | Heat shock protein beta-1 | 3.27 | 9.51E-04 |
| HSPD1 | 60 kDa heat shock protein, mitochondrial | 3.42 | 5.93E-04 |
| HSPH1 | Heat shock protein 105 kDa | 3.18 | 1.22E-03 |
| HSPA8 | Heat shock cognate 71 kDa protein | 3.11 | 1.49E-03 |
| AHSA1 | Activator of 90 kDa heat shock protein ATPase homolog 1 | 2.49 | 7.88E-03 |
| HSP90B1 | Heat shock protein 90kDa beta (Grp94), member 1 | 2.43 | 9.33E-03 |
-Transcriptional profiling data derived from the analysis of N=28 breast cancer patients are shown, high-lighting the levels of fold-upregulation observed in the epithelial cancer cell compartment (relative to the tumor stroma), and corresponding p-values derived from the analysis of these clinical samples.
-Proteins listed above (10 in total) were all upregulated either in MCF7 or T47D mammospheres (See Tables 3 & 4).