Table 1. Immune cell infiltrate in 291 cases of meningioma scored by Aperio digital algorithms (separated into low and high expressors - relative to the median score for each marker for the entire cohort; TMA 283 & 285 & 310).
| Meningioma types | # of Cases | LCA | CD3 | CD4 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | Percent | Low | High | Percent | Low | High | Percent | ||
| WHO grade I | 195 | 83 | 103 | 55.38% | 91 | 103 | 53.09% | 98 | 96 | 49.48% |
| Meningothelial | 68 | 22 | 43 | 31 | 37 | 36 | 32 | |||
| Fibrous | 46 | 25 | 20 | 22 | 24 | 29 | 17 | |||
| Transitional | 52 | 20 | 31 | 22 | 30 | 23 | 29 | |||
| Angiomatous | 11 | 6 | 4 | 6 | 5 | 4 | 7 | |||
| Psammomatous | 9 | 3 | 3 | 3 | 5 | 2 | 6 | |||
| Secretory | 9 | 7 | 2 | 7 | 2 | 4 | 5 | |||
| WHO grade II | 73 | 41 | 31 | 43.06% | 39 | 34 | 46.58% | 35 | 37 | 51.39% |
| Atypical | 68 | 36 | 31 | p = 0.076 | 38 | 30 | p = 0.342 | 32 | 35 | p = 0.783 |
| Chordoid | 5 | 5 | 0 | 1 | 4 | 3 | 2 | |||
| WHO grade III | 23 | 17 | 6 | 26.09% | 16 | 7 | 30.43% | 18 | 5 | 21.74% |
| Anaplastic | 23 | 17 | 6 | p = 0.008 | 16 | 7 | p = 0.040 | 18 | 5 | p = 0.012 |
| CD8 | CD20 | FOXP3 | PD-1 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | Percent | Low | High | Percent | Low | High | Percent | Low | High | Percent |
| 89 | 105 | 54.12% | 120 | 74 | 38.14% | 114 | 79 | 40.93% | 105 | 89 | 45.88% |
| 29 | 39 | 38 | 30 | 42 | 26 | 30 | 38 | ||||
| 20 | 26 | 35 | 11 | 27 | 19 | 25 | 21 | ||||
| 21 | 31 | 33 | 19 | 26 | 25 | 29 | 23 | ||||
| 6 | 5 | 5 | 6 | 7 | 4 | 8 | 3 | ||||
| 5 | 3 | 5 | 3 | 5 | 3 | 5 | 3 | ||||
| 8 | 1 | 4 | 5 | 7 | 2 | 8 | 1 | ||||
| 39 | 34 | 46.58% | 46 | 27 | 36.99% | 26 | 47 | 64.38% | 33 | 38 | 53.52% |
| 37 | 31 | p = 0.271 | 43 | 25 | p = 0.862 | 24 | 44 | p = 0.001 | 29 | 37 | p =0.270 |
| 2 | 3 | 3 | 2 | 2 | 3 | 4 | 1 | ||||
| 17 | 6 | 26.09% | 17 | 6 | 26.09% | 5 | 18 | 78.26% | 18 | 5 | 21.74% |
| 17 | 6 | p = 0.011 | 17 | 6 | p =0.257 | 5 | 18 | p = 0.001 | 18 | 5 | p = 0.027 |
The numbers of LCA, CD3, CD4, CD8, CD20, and FOXP3 positive cells were counted using Aperio Imagescope software and the number of PD-1 positive cells was counted by visual microscopic review. The percentage of cases with low or high infiltration are presented for each marker (< or > the median score across all of the samples in the cohort for each marker, respectively).