Table 2. Effect of regorafenib and CRT0066101 on human CRC growth.
| Cell Line | regorafenib | CRTOO661O1 |
|---|---|---|
| HCT116(p53+/+) | 2.90 ± 0.45 | 0.98 ± 0.13 |
| HCT116 (p53−/−) | 3.17 ± 0.51 | 1.01 ± 0.06 * |
| RKO | 3.07 ± 0.06 | 1.05 ± 029 |
| HT29 | 5.89±0.88 | 4.12±0.57 |
| SW48 | 4.98 ± 0.45 | 3.42 ± 0.39 |
| SW48-TP53(R273H/+) | 5.01 ± 0.32 | 3.37 ± 0.35 |
| CCD-841 | 3.36 ± 0.27 | 5.02 ± 0.16 |
The cytotoxic effects of regorafenib and CRTOO66IOI on CRC growth were determined by the WST-I assay. IC50 (μM) was calculated by Prisrn5.0 software. Values represent the mean ± SD of3 independent experiments performed in duplicate.
*
previously published [18].