Skip to main content
. 2014 Dec 31;6(7):4863–4887. doi: 10.18632/oncotarget.3120

Figure 9. HDAC1,2 inhibition sensitizes chemoresistant Karpas-422 cells to doxorubicin induced cell death.

Figure 9

A: Karpas-422 cells were treated with DMSO, 2μM ACY-957, 50 nM doxorubicin or ACY-957 plus 50nM doxorubicin for 48h. Cell cycle analysis of propidium-iodide stained cells was performed with fixed cells. Representative plots from five independent experiments are shown in the figure. B: The graph represents average percentage cells +/− standard error of five independent experiments. *p= 0.003, **p= 0.005. C: FACS analysis following BrdU-PI staining of Karpas-422 cells was performed following a treatment with 2μM ACY-957, 50nM doxorubicin or both for 48h. Representative plots from two independent experiments are shown in the figure.