Table 4. Univariate and multivariate Cox regression of NMI expression for overall survival and progression-free survival in GBM patients of the TCGA cohort (the Affymetrix platform).
| Characteristics | Univariate Cox Regression | Multivariate Cox Regression | ||
|---|---|---|---|---|
| P | HR (95% CI) | P | HR (95% CI) | |
| OS | ||||
| Gender (male vs. female) | 0.464 | |||
| Age (≥60 vs. <60) | 1.42E-10 | 1.94(1.58-2.37) | 3.97E-04 | 1.72(1.28-2.33) |
| Tumor origin (Secondary vs. Primary) | 4.42E-05 | 0.39(0.25-0.62) | 0.001 | 0.39(0.22-0.69) |
| MGMT (methylated vs. unmethylated) | 0.002 | 0.67(0.52-0.87) | 0.025 | 0.72(0.54-0.96) |
| G-CIMP (positive vs. negative) | 3.39E-08 | 0.32(0.21-0.48) | 0.177 | |
| Subtype (proneural vs. non-proneural) | 0.038 | 0.79(0.63-0.99) | 0.124 | |
| PTEN (deletion vs. wild type) | 0.001 | 1.64(1.23-2.18) | 0.149 | |
| EGFR (amplification vs. wild type) | 1.07E-04 | 1.85(1.35-2.52) | 0.252 | |
| PARK2 (deletion vs. wild type) | 0.529 | |||
| PDGFRA (amplification vs. wild type) | 0.287 | |||
| CDK6 (amplification vs. wild type) | 0.002 | 1.50(1.16-1.92) | 0.223 | |
| RB1 (deletion vs. wild type) | 0.953 | |||
| IDH1 (mutation vs. wild type) | 1.00E-04 | 0.37(0.23-0.61) | 0.783 | |
| NMI expression (high vs. low) | 0.001 | 1.49(1.19-1.87) | 0.021 | 1.54(1.07-2.23) |
| PFS | ||||
| Gender (male vs. female) | 0.35 | |||
| Age (≥60 vs. <60) | 7.77E-05 | 1.57(1.25-1.96) | 0.489 | |
| Tumor origin (Secondary vs. Primary) | 1.82E-06 | 0.29(0.18-0.49) | 7.74E-06 | 0.21(0.10-0.41) |
| MGMT (methylated vs. unmethylated) | 0.025 | 0.73(0.55-0.96) | 0.008 | 0.65(0.47-0.89) |
| G-CIMP (positive vs. negative) | 4.30E-07 | 0.29(0.18-0.47) | 0.255 | |
| Subtype (proneural vs. non-proneural) | 0.038 | 0.76(0.59-0.99) | 0.045 | 1.58(1.01-2.45) |
| PTEN (deletion vs. wild type) | 0.003 | 1.64(1.18-2.29) | 0.698 | |
| EGFR (amplification vs. wild type) | 4.56E-05 | 2.20(1.51-3.21) | 0.281 | |
| PARK2 (deletion vs. wild type) | 0.743 | |||
| PDGFRA (amplification vs. wild type) | 0.807 | |||
| CDK6 (amplification vs. wild type) | 0.025 | 1.38(1.04-1.82) | 0.358 | |
| RB1 (deletion vs. wild type) | 0.97 | |||
| IDH1 (mutation vs. wild type) | 0.015 | 0.50(0.29-0.87) | 0.26 | |
| NMI expression (high vs. low) | 0.003 | 1.45(1.13-1.85) | 0.033 | 1.55(1.04-2.32) |
Abbreviations: G-CIMP, Glioma-CpG Island Methylator Phenotype; OS, overall survival; PFS, progression-free survival; HR, hazard ratio; CI, confidence interval.