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. 2014 Dec 31;6(7):5102–5117. doi: 10.18632/oncotarget.3244

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Copyright: © 2015 Matsushita et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) The weight of thymus of FIR^+/−P53^−/− and FIR^+/+P53^−/− was significantly heavier than that of wild or FIR^+/−P53^+/+ mouse (P<0.05). The weight of spleen of FIR^+/+P53^{−/− -}were significantly heavier than that of wild or FIR^+/−P53^+/+ mouse (P<0.05). The weight of liver of wild mouse, FIR^+/−P53^+/+, FIR^+/+P53^−/−, and FIR^+/−P53^−/− was no significant difference. (B) WBC count of FIR^+/−P53^−/− and FIR^+/+P53^−/− was significantly increased than that of wild mouse. RBC count of FIR^+/+P53^−/− was significantly less than that of wild mouse (P<0.05). Platelet count of FIR^+/−P53^−/− and FIR^+/+P53^−/− was significantly less than that of wild or FIR^+/−P53^+/+ mouse (P<0.05). (C) Body weight of FIR^+/−P53^−/− mice was significantly lighter than that of FIR^+/+P53^−/−. Statistical signifincace was calculated by Student's t-test. (D) The overall survival curves of four genetically different group: wild, FIR^+/−p53^+/+, FIR^+/−p53^−/−, and FIR^+/+p53^−/− mice. FIR^+/−p53^+/+ and FIR^+/+p53^+/+ were survived 100% up to 25 weeks after birth without obvious tumor formation, body weight loss or other physical disabilities. On the contrary, the overall survival curves (Kaplan-Meier method) of FIR^+/−p53^−/− and FIR^+/+p53^−/− mice were declined around 70 days after birth. Overall survival curves of four genetically different group: wild, FIR^+/−p53^+/+, FIR^+/−p53^−/−, and FIR^+/+p53^−/− mice were compared by log-rank test. (E) T-ALL with more than 10 % bone marrow infiltration of blast cells in FIR^+/−P53^−/− mice was 5 out of 23 (21.7%) including three pre-analytical alive mouse in FIR^+/+P53^−/− (1 out of 19=5.3%) including two pre-analytical alive mouse. (F) In FIR^+/−P53^−/− mice (N=23), T-ALL: 10 (50.0%), thymic lymphoma: 15 (75%), bone marrow invasion: 5 (25.0%). Whereas in FIR^+/+P53^−/− mice (N=17) T-ALL: 7 (41.2%), thymic lymphoma: 10 (58.8%), bone marrow invasion: 1 (5.9%). Blank in colored column indicated undetermined or not tested for cell surface marker.