Skip to main content
. 2014 Sep 16;6(7):5204–5216. doi: 10.18632/oncotarget.2477

Figure 3. Overview of results from different analyses.

Figure 3

Numbers listed represent the number of miRNAs. (A) Of 470 screened miRNAs, 29 miRNAs interact with the 3′UTR of MYCN. (B) Of these 29 miRNAs, 25 miRNAs could subsequently be analyzed in primary neuroblastoma tumors: 12 miRNAs are inversely correlated to MYCN expression or activity, whereas 5 miRNAs are positively correlated to MYCN expression or activity. (C) Of the 12 miRNAs inversely correlated to MYCN expression or activity, 10 miRNAs are downregulated during MYCN-driven tumor development in the TH-MYCN mouse model, 9 miRNAs are lower expressed in LSL-MYCN;Dbh-iCre tumors compared to wild-type adrenals, and 2 miRNAs are repressed upon induction of MYCN in the SHEP-MYCN-ER model system. On the other hand, of the 5 miRNA correlated to MYCN expression or activity, 3 miRNAs are upregulated during MYCN-driven tumor development in the TH-MYCN mouse model, these miRNAs are also higher expressed in LSL-MYCN;Dbh-iCre tumors compared to wild-type adrenals, and 3 miRNAs are induced upon induction of MYCN in the SHEP-MYCN-ER model system.