Figure 4. Frequency of driver gene mutations according to predominant histologic subtype.

(A) Lepidic, (B) Acinar, (C) Papillary, (D) Solid, (E) Mucinous subtype. In acinar subtype, four cases with concurrent mutations of EGFR/PIK3CA (n = 3) and EGFR/TP53 (n = 1) are represented as an EGFR mutation, and 2 cases of ALK/TP53 mutation as an ALK mutation. In mucinous subtype, two cases with concurrent mutations of KRAS/PIK3CA and KRAS/ERBB2 are represented as a KRAS mutation.